490pcombining Cytotoxic Chemotherapy with Antiangiogenic Agents and Complete Responses in Cancer Patients: a Meta Analysis of Published Trials.

Aim: The approach of combining chemotherapy with antiangiogenic agents(AAs) has been explored in many trials. In most cases, the addition of AAs to chemotherapy have shown greater activity compared to chemotherapy alone. However, a clinically relevant increase in complete responses (CRs), which is a rare but important event in patients receiving chemotherapy, was not reported. We meta-analyzed the incidence and risk of CRs in patients treated with AAs and chemotherapy in randomized controlled trials (RCTs) for first-line therapy of cancer.